Phenoxypropanolpiperazines

Details Phenoxypropanolpiperazines Phenoxypropanolpiperazines

1974-08-02

1976-04-20

Narcavage, Joseph A.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260348A, 260348R, 424250, C07D29512

Patent

active

039519830

ABSTRACT:
A series of novel substituted phenoxypropyl piperazine derivatives have been prepared by reacting the appropriate 1-phenoxy-2,3-epoxypropane compound with 1-phenoxy-3-(4-phenylpiperazine-1-yl)propan-2-ols suitable N-phenylpiperazine reagent. The resulting 1-phenoxy13-(4-phenylpiperazine-1-yl)propan-2-ols are useful in the field of chemotherapy as antihypertensive agents. Preferred members include compounds having an acetamidomethyl, carboxymethyl or carbamoylmethyl group substituted on the phenyl ring of the phenoxy moiety. Alternate methods of preparation are also provided.

REFERENCES:
patent: 3480624 (1975-06-01), Fouche
patent: 3701777 (1972-10-01), Edenhofer et al.
patent: 3856794 (1974-12-01), Danilewicz et al.
V. P. Arya et al., J. of Pharmaceutical Sciences, Vol. 58, No. 4, Apr. 1969, pp. 432-440.
P. C. Das et al., J. of Medicinal Chemistry, Vol. 14, No. 9, pp. 890-891, (1971).
Burger, Medicinal Chemistry, 2nd Ed. p. 42 (1960).

Affiliated with

Also associated with

Rating

Phenoxypropanolpiperazines does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Phenoxypropanolpiperazines, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Phenoxypropanolpiperazines will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1587273