Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1991-05-22
1994-06-28
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514266, 544243, 544244, 544265, 544276, 544277, A61K 3152, C07D47318, C07D47332, C07F 909
Patent
active
053247302
ABSTRACT:
This invention relates to cyclobutane derivatives represented by the following general formula (1) and physiologically acceptable salts thereof: ##STR1## wherein B represents a nucleic acid base derivative, R.sup.1 and R.sup.2 independently represent hydrogen atom, dialkylaminoacyl group, 1,4-dihydro-1-methylnicotinoyl group or substituted phosphoric acid group, provided that either one of R.sup.1 and R.sup.2 is a group other than hydrogen atom.
The compounds of this invention exhibit a high oral absorbability and are metabolized in vivo into the compounds of formula (1a). Accordingly, the compounds of this invention are expectedly useful as antiviral agent.
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Akaba Hiroshi
Ichikawa Yuh-ichiro
Kato Sayuri
Matsubara Kenichi
Nagahata Takemitsu
Gupta Y. N.
Nippon Kayaku Kabushiki Kaisha
Shah Mukund J.
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