Phenoxyphenylacetic acid derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...

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5142312, 514255, 514256, 514428, 514452, 544146, 544153, 544242, 544336, 549220, 549362, 549434, 549469, 562446, 562447, 562466, 562467, A61K 3119, A61K 31535, C07D26530, C07C 5911

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active

056681763

ABSTRACT:
Phenoxyphenylacetic acids and derivatives of the general structural formula I ##STR1## have endothelin antagonist activity and are useful in treating cardiovascular disorders, such as hypertension, postischemic renal failure, vasospasm, cerebral and cardiac ischemia, myocardial infarction, endotoxic shock, benign prostatic hyperplasia, inflammatory diseases including Raynaud's disease and asthma.

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