Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1998-03-24
2000-08-29
Morris, Patricia L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514331, 546232, 546236, 546240, A61K 31452, C07D21118
Patent
active
061109371
ABSTRACT:
Compounds selected from the group of compounds represented by Formula I: ##STR1## as an individual isomer or as a racemic or non-racemic mixture of isomers, and their pharmaceutically acceptable salts and N-oxides thereof; are sodium channel blockers, and thus exhibit useful pharmacological properties, including utility for the treatment of neuropathic pain conditions.
REFERENCES:
patent: 3634437 (1972-01-01), Todd
patent: 3709892 (1973-01-01), Leeming et al.
patent: 4508724 (1985-04-01), Taylor, Jr. et al.
patent: 4822778 (1989-04-01), Aberg et al.
patent: 4877799 (1989-10-01), Drejer et al.
patent: 4985446 (1991-01-01), Drejer et al.
patent: 5019582 (1991-05-01), Drejer et al.
patent: 5158961 (1992-10-01), Jakobsen et al.
patent: 5210086 (1993-05-01), George et al.
patent: 5227379 (1993-07-01), Jakobsen et al.
Arya et al., Indian J. Chem (1977), vol. 15B, pp. 1125-1128, "Synthesis & CNS Depressant Activity of Some Pyridyl & Piperidyl Ethers".
Balsamo et al., J. Med. Chem. (1987), vol. 30, pp. 222-225, "3-[(2-Ethoxyphenoxy)methyl]piperidine Derivatives. Synthesis and Antidepressant Activity".
Catterall, Trends in Pharmacological Science, vol. 8, No. 2, pp. 57-65 (1987), "Common Modes of Drug Action on Na+ Channels: Local Anesthetics, Antiarrhythmics and Anticonvulsants".
Ragsdale et al, Molecular Pharmacology, vol. 40, No. 5, pp. 756-765 (1991), "Frequency and Voltage-Dependent Inhibition of Type IIA Na+ Channels, Expressed in a Mammalian Cell Line, by Local Anesthetic, Antiarrhythmic, and Anticonvulsant Drugs".
Tolatsky et al, Cardiovascular Drug Review, vol. 7, No. 3, pp. 199-209 (1989), "K+ Channel Blockers and Activators in Cardiac Arrhythmias".
Hondeghem et al, Annual Review. Pharmacol. Toxicol, vol. 24, pp. 387-423 (1984), Antiarrhythmic Agents: The Modulated Receptor Mechanism of Action of Sodium and Calcium Channel-Blocking Drugs.
Roufos et al, Journal of Medical Chemistry, vol. 39, No. 7, pp. 1514-1520 (1996), "A Structure-Activity Relationship Study of Novel Phenylacetamides Which are Sodium Channel Blockers".
Journal of Medical Chemistry, vol. 37, No. 2, pp. 268-274, (1994), "Synthesis and Pharmacological Evaluation of Phenylacetamides as Sodium-Channel Blockers".
Flippin Lee Allen
Lin Xiao-Fa
Loughhead David Garrett
Weikert Robert James
Kaku Janet
Morris Patricia L.
Peries Rohan
Syntex (USA) Inc.
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