Phenoxyalkanol derivatives

Details Phenoxyalkanol derivatives Phenoxyalkanol derivatives

1976-06-09

1977-09-27

Helfin, Bernard

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

260613R, 260287R, 260289R, 2603455, 26032647, 2603261, 2603265M, 26029383, 260327R, 424341, 424311, 424274, 424267, 424258, C07C 6906, C07C 4320

Patent

active

040511731

ABSTRACT:
Phenoxylakanols of the formula ##STR1## wherein R.sup.1 is H or CH.sub.3 ; R.sup.2 is CH.sub.3 or C.sub.6 H.sub.5 ; R.sup.3 is 4-Hal-phenoxymethyl, 1,2,3,4-tetrahydro-1-naphthyl, 1-pyrryl, piperidino, isoindoline, 1,2,3,4-tetrahydroquinoline, 1,2,3,4-tetrahydro-1-R.sup.5 -4-quinolyl, 4-chromanyl, 4-thiochromanyl, or, when at least one of R.sup.1 and R.sup.2 is other than CH.sub.3, also Hal, phenyl, 4-Hal-phenyl or 4-Hal-phenoxy, wherein R.sup.4 is H or alkanoyl of 2-4 carbon atoms, R.sup.5 is H or CH.sub.3 and Hal if F, Cl or Br; and physiologically acceptable acid addition salts thereof possess pharmacological activity, particularly cholesterol, triglyceride and uric acid blood-level lowering activity and are also useful as intermediates for the production of the corresponding phenoxyacetic acids.

REFERENCES:
patent: 3363003 (1968-01-01), Bolhofer
patent: 3804839 (1974-04-01), Dahm et al.
patent: 3981905 (1976-09-01), Adams et al.

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