Phenoxy-hydroxypropylamines, their preparation, and method and p

Details Phenoxy-hydroxypropylamines, their preparation, and method and p Phenoxy-hydroxypropylamines, their preparation, and method and p

1976-08-31

1979-03-20

Hines, Robert V.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

260307C, 26034857, 26050117, 26050119, 260562R, 2605675, 2605707, 260600R, 424316, A61K 31135, C07C 9306

Patent

active

041454421

ABSTRACT:
Ortho-para-substituted phenoxy-hydroxypropylamines having the general formula ##STR1## and pharmaceutically acceptable, non-toxic acid addition salts thereof, wherein R.sup.1 is alkyl or hydroxyalkyl, R.sup.2 is alkoxyalkyl or alkylthioalkyl, and R.sup.3 is halogen, alkyl, alkenyl, alkinyl, alkoxymethyl, or alkoxy are disclosed, as are methods for their preparation.
Pharmaceutical preparations are prepared whose active ingredients include at least one of the newly discovered phenoxy-hydroxypropylamine compounds. Therapeutically effective doses of these preparations selectively block the .beta.-receptors of the heart making them useful in treating heart diseases in animals including humans.

REFERENCES:
patent: 3275654 (1966-09-01), Wilhelm et al.
patent: 3644469 (1975-02-01), Koppe et al.
patent: 3755413 (1973-08-01), Koppe et al.
patent: 3876802 (1975-04-01), Brandstrom et al.

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