Phenoxy carboxylic acid derivatives as anti-atheroslerosis agent

Details Phenoxy carboxylic acid derivatives as anti-atheroslerosis agent Phenoxy carboxylic acid derivatives as anti-atheroslerosis agent

1974-04-10

1976-05-25

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

424317, A61K 31235

Patent

active

039594840

ABSTRACT:
Novel anti-atheroscelersosis agents having the formula, ##SPC1##
Wherein typical examples of R.sup.1 and R.sup.2 are hydrogen, C.sub.1 -C.sub.8 alkyl, phenyl, benzyl and phenethyl, or R.sup.1 and R.sup.2 may form cycloalkylidene together with a carbon atom bonded therewith; R.sup.3 and R.sup.4 each is hydrogen or C.sub.1 -C.sub.4 alkyl; Y is hydroxyl, C.sub.1 -C.sub.4 alkoxy, phenoxy or an amine residue; A is hydrogen or a group of the formula, ##EQU1## wherein R.sup.3, R.sup.4 and Y have the same meanings as defined above; and D and E each is hydrogen or halogen.
These compounds are produced, for example, by reacting a bisphenolic compound of the formula, ##SPC2## with chloroform and a ketone compound of the formula,

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patent: 3630715 (1971-12-01), Guttag
patent: 3652646 (1972-03-01), Leigh et al.
patent: 3755603 (1973-08-01), Harrison et al.

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