Phenoxy and phenylthio, amino substituted benzocycloalkane deriv

Details Phenoxy and phenylthio, amino substituted benzocycloalkane deriv Phenoxy and phenylthio, amino substituted benzocycloalkane deriv

1991-03-13

1992-07-28

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514657, 514463, 514464, A61K 31135, A61K 31335, A61K 3136

Patent

active

051341689

ABSTRACT:
Drug-resistant protozoal infection, particularly, drug-resistant malarial infection in humans, can be effectively treated with standard antiprotozoal agents if administered in conjunction with a phenoxyamino-substituted benzocycloalkane derivative.

REFERENCES:
patent: 4177292 (1979-12-01), Nedelec et al.
Hewlett, E. L. and Pearson, R. D., Science, vol. 230 pp. 1063-1064 (1985).
Zilberstein, D. and Dwyer, D. M., Science: 226, 977-9 (1984).
P. Dutta et al., Clinical Pharmacology: 279 (1986).
T. B. Geary, et al., Antimicrobial Agents and Chemotherapy, pp. 785-788 (1986).
L. W. Scheibel et al., Proc. Natl. Acad. Sci., USA, vol. 84, pp. 7310-7314, (1987).

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