Phenothiazine derivatives, their production and use

Details Phenothiazine derivatives, their production and use Phenothiazine derivatives, their production and use

1994-05-23

1996-07-02

Ceperley, Mary E.

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

Carrier is organic

436503, 436512, 436544, 436546, 436811, G01N 33546, G01N 33567

Patent

active

055321712

ABSTRACT:
There is disclosed a novel phenothiazine derivative of the general formula (I): ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are the same or different and are a C.sub.1-6 alkyl group and at least one of them has as a substituent a group which can react with amino group, thiol group or carboxyl group, and X.sup.- is a counter ion of the phenazathionium. Their production and the intermediates used in the production are also disclosed. The compound (I) is a derivative of methylene blue and is applicable to photodynamic therapy of cancer or immunoassays utilizing chemiluminescence.

REFERENCES:
patent: 3873340 (1975-03-01), Miyazawa et al.
patent: 4652643 (1987-03-01), Gunn et al.
patent: 4714763 (1987-12-01), Theodoropulos
patent: 4962197 (1990-10-01), Foley et al.
M. Motsenbocker et al., Anal. Chem, vol. 65, pp. 403-408 (1993).
M. Motsenbocker et al., Photochemistry and Photobiology, vol. 58, No. 5, pp. 648-652 (1993).

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