Phenothiazine derivative

Details Phenothiazine derivative Phenothiazine derivative

1975-10-10

1976-10-19

Moatz, Harry I.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424247, C07D45302

Patent

active

039870421

ABSTRACT:
Phenothiazine derivatives are described of the formula ##SPC1##
In which X.sub.1 and X.sub.2, which may be the same or different, are H, R, F, Cl, Br, OR, CN, --COR, CH.sub.3, --S--R, --SOR, --SO.sub.2 R or --SO.sub.2 N(CH.sub.3).sub.2, where R is an alkyl group having from 1 to 4 carbon atoms, and the quinuclidine ring is substituted by the group --(CH.sub.2).sub.x -- in the 2- or 3- position, x being 1 or 2 when said group is substituted in the 2-position and being 0 or 1 when said group is substituted in the 3-position (because of electronic hindrance), and their acid addition and quaternary ammonium salts, have valuable pharmacological properties. In particular, these compounds have anti-histaminic, anti-cholinergic, adrenolytic, neuro-sedative, tranquillizing and/or spasmolytic properties.
These compounds are prepared by condensing an appropriate phenothiazine with a quinuclidine derivative of the formula ##SPC2##
In which x has the above-stated meaning and Z is a halogen atom or a reactive ester group.

REFERENCES:
patent: 2945855 (1960-07-01), Feldkamp et al.
patent: 3140284 (1964-07-01), Habicht et al.
patent: 3360526 (1967-12-01), Minor
patent: 3370058 (1968-02-01), Judd et al.

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