Phenolic thioethers, and their production and use

Details Phenolic thioethers, and their production and use Phenolic thioethers, and their production and use

1989-05-31

1992-01-28

Dees, Jose G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

514824, 568 38, 568 54, 568 67, C08H 0300

Patent

active

050842145

ABSTRACT:
Phenolic thioethers of the formula: ##STR1## wherein R is a hydrogen atom or a protective group for carboxyl, X is a straight or branched C.sub.4 -C.sub.15 alkylene group, a straight or branched C.sub.1 -C.sub.15 alkylene group having a phenylene group or a straight or branched C.sub.2 -C.sub.15 alkenylene group, and their salts, which inhibit the denaturation of low density lipoproteins (LDL) and the incorporation of LDL by macrophages and are useful as anti-arteriosclerosis agents.

REFERENCES:
patent: 4012523 (1977-03-01), Wagner
patent: 4076841 (1978-02-01), Wagner, et al.
Tsuda et al., Chemical Abstracts, 90: 151802X, pg. 575, 1979.
Wagner et al., J. Medeanal Chemistry, vol 20, #8, 1977, pg. 1007-1013.
Chemical Abstracts, 85:14147V, p. 65, 1976.
Tsuda et al., Chemical Abstracts, 90: 1518024, p. 575, 1979.
Chemical Abstracts, vol. 94, No. 5, Feb. 2, 1981, Col. 30290 C.
Proc. Natl. Acad. Sci. U.S.A., vol. 85, pp. 2344-2348, Apr. 1988, Medical Sciences.
J. Clin. Invest., vol. 81, Mar. 1988, pp. 720-729.

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