Phenolic thioetheramides

Details Phenolic thioetheramides Phenolic thioetheramides

1993-12-09

1994-08-30

Sigel, Alan

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

5142275, 5142278, 5142375, 5142355, 514255, 514315, 514316, 544 584, 544130, 544158, 544360, 544386, 546189, 546245, A61K 3150, C07D27912, C07D, C07D

Patent

active

053428382

ABSTRACT:
The present invention relates to phenolic thioetheramides of the formula ##STR1## wherein R.sup.1 and R.sup.2 are tert-alkyl or phenyl, Alk.sup.1 and Alk.sup.2 are alkylene; X is sulfur or oxygen, m is 0, 1, or 2; and R is ##STR2## wherein R.sup.3 and R.sup.4 are hydrogen or alkyl and Alk.sup.3 is alkylene; or ##STR3## wherein Y is CH, N, O, or S; R.sup.6 is hydrogen, alkyl, phenyl, substituted phenyl, benzyl, substituted benzyl or a heterocyclic amine; and R.sup.7 is hydrogen or alkyl. The compounds inhibit 5-lipoxygenase and are useful in the treatment of inflammation and allergic conditions.

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