Phenolic thioalkylamides as inhibitors of 5-lipoxygenase

Details Phenolic thioalkylamides as inhibitors of 5-lipoxygenase Phenolic thioalkylamides as inhibitors of 5-lipoxygenase

1987-06-05

1989-05-30

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

A61K 31165

Patent

active

048351890

ABSTRACT:
The compounds of the present invention comprise substituted phenolic thioalkylamides that are specific inhibitors of 5-lipoxygenase and which, therefore, are useful in the treatment of local and systemic inflammation, allergy and hypersensitivity reactions and other disorders in which agents formed in the 5-lipoxygenase metabolic pathway are involved.

REFERENCES:
patent: 3392194 (1968-07-01), Waring et al.
patent: 3624143 (1971-11-01), Shen et al.
patent: 3652646 (1972-03-01), Leighh et al.
patent: 4029812 (1977-01-01), Wagner et al.
patent: 4076841 (1978-02-01), Wagner et al.
patent: 4078084 (1984-03-01), Wagner et al.
patent: 4153803 (1979-05-01), Thiele et al.
patent: 4528286 (1985-07-01), Moller et al.
patent: 4534874 (1985-08-01), Steinberg et al.
Samuelsson, "Leukotrienes: Mediators of Immediate Hypertensitivity Reactions and Inflammation", Science, vol. 220, 1983, p. 568-57.
Bach, "Inhibitors of Leukotriene Synthesis and Action", The Leukotrienes Chemistry and Biology, Academic Press, pp. 163-194, (1984).
Lee et al., "Human Biology and Immunoreactivity of Leukotrienes", Advances in Inflammation Research, vol. 6, pp. 219-225, Raven Press, (1984).
Editorial, "Leukotrienes and Other Lipoxygenase Products in the Pathegonesis and Therapy of Psoriasis and Dermatoses", Arch. Dermatol., vol. 119, pp. 541-547, (Jul. 1983).
Lewis et al., "A Review of Recent Contributions on Biology Active Products of Arachidonate Conversion", Int. J. Immunopharma, vol. 4, No. 2, pp. 85-90, (1982).
Bach, "Prospects for the Inhibition of Leukotriene Synthesis", Biochemical Pharmacology, vol. 33, No. 4, pp. 515-521, (1984).
Becker, "Chemotactic Factors of Inflammation", pp. 223-225, (Elsevier Science Publishers B.V. Amsterdam, 1983).
Sharon et al., "Enhanced Synthesis of Leukotriene B.sub.4 by Colonic Mucosa in Inflammatory Bowel Disease", Gastroenterology, vol. 86, pp. 453-460, (1984).
Musch et al., "Stimulation of Colonic Secretion by Lipoxygenase Metabolites of Arachidonic Acid", Science, vol. 217, p. 1255, (1982).
Harvey et al., "The Preferential Inhibition of 5-Lipoxygenase Product Formation by Benoxaprofen", J. Pharm. Pharmacol., vol. 35, pp. 44-45, (1983).
Chem. Abst., 90:151802x, vol. 90, (1979).
Khim. Tekhnol., 20(4), pp. 568-574, (1977).

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