Phenolic thioalkylamides as inhibitors of 5-lipoxygenase

Details Phenolic thioalkylamides as inhibitors of 5-lipoxygenase Phenolic thioalkylamides as inhibitors of 5-lipoxygenase

1989-03-09

1991-11-19

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514617, 564161, 564162, A61K 3165, C07C32322

Patent

active

050666797

ABSTRACT:
The compounds of the present invention comprise substituted phenolic thioalkylamides that are specific inhibitors of 5-lipoxygenase and which, therefore, are useful in the treatment of local and systemic inflammation, allergy and hypersensitivity reactions and other disorders in which agents formed in the 5-lipoxygenase metabolic pathway are involved.

REFERENCES:
patent: 4029812 (1977-06-01), Wagner et al.
patent: 4327111 (1982-04-01), Sundeen et al.
patent: 4329363 (1982-05-01), Dorn et al.
Muller et al., "Hydroxyphenylthio-Substituted Anilides", CA 105, 208614x, Dec. 8, 1986.

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