Phenolic amino-carboxylic acid radiopharmaceuticals

Details Phenolic amino-carboxylic acid radiopharmaceuticals Phenolic amino-carboxylic acid radiopharmaceuticals

1976-02-03

1978-05-09

Padgett, Benjamin R.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Molecular bilayer structure

260518R, 424 9, 2604297, A61K 2700, A61K 4300

Patent

active

040887472

ABSTRACT:
A radiopharmaceutical for use on animals including human beings comprises a metal chelate in which the chelating agent is a phenolic amino carboxylic acid or an alkali salt thereof, and the metal is a pharmaceutically acceptable radio isotope such as technetium-99m. The chelating agent may be advantageously an ethylenediamine carboxylic acid or its salt having a phenolic group at each end of the molecule such as EDDHA and HBED or alternatively the phenolic amino carboxylic acid or its salt may have a single phenolate group such as HBG or HBS. The pharmaceutical has a balance of lipo-solubility and water-solubility to permit hepato-biliary imaging.

REFERENCES:
patent: RE23905 (1954-12-01), Bersworth
patent: 2624757 (1953-01-01), Bersworth
patent: 3509208 (1970-08-01), Alburn et al.
patent: 3749556 (1971-08-01), Barak et al.
patent: 3833590 (1974-09-01), Dazzi

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