Phenolic amino-carboxylic acid complexes for forming radiopharma

Details Phenolic amino-carboxylic acid complexes for forming radiopharma Phenolic amino-carboxylic acid complexes for forming radiopharma

1976-09-30

1978-05-23

Padgett, Benjamin R.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Molecular bilayer structure

260518R, 424 9, 2604297, A61K 2700, A61K 4300

Patent

active

040910881

ABSTRACT:
A complex of a chelating agent is formed and labelled with technetium-99m. The chelating agent is either an ethylenediamine carboxylic acid or its salt having a phenolic group at each end of the molecule such as EDDHA and HBED or alternatively the phenolic amino carboxylic acid or its salt having a single phenolate group such as HBG or HBS. The complex is a stannous complex which when labelled with technetium-99m has a good balance of lipo-solubility and waater-solubility to permit hepato-biliary imaging. The radiopharmaceutical may be useful for assessing hepatobiliary function in animals including human beings. A particularly useful chelating agent is ethylene-bis-(.alpha.-imino-2-hydroxy-5-bromophenyl acetic acid).

REFERENCES:
patent: RE23905 (1954-12-01), Bersworth
patent: 2624757 (1953-01-01), Bersworth
patent: 3509208 (1970-08-01), Alburn et al.
patent: 3749556 (1971-08-01), Barak et al.
patent: 3833590 (1974-09-01), Dazzi
patent: 3928552 (1975-12-01), Winchell et al.
patent: 3931396 (1976-01-01), Bardy et al.

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