Phenol substituted gem-diphosphonate derivatives, process for th

Details Phenol substituted gem-diphosphonate derivatives, process for th Phenol substituted gem-diphosphonate derivatives, process for th

1989-03-14

1991-08-27

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

558161, 558 77, 558 83, 562 19, 562 21, C07F 958, C07F 940, A61K 31675

Patent

active

050433300

ABSTRACT:
The invention relates to new gem-diphosphonates derivatives substituted by phenol groups of formula (I): ##STR1## as well as the process for their preparation and the pharmaceutical compositions containing them.

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"Reduction in Incidence of Coronary Heart Disease", Journal of The American Medical Association, vol. 251, No. 3, Jan. 1984, pp. 351-364.
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"Helsinki Heart Study: Primary-Prevention trial with Gemfibrozil in Middle-Aged Men with Dysliphidemia", The New England Journal of Medicine, vol. 317, No. 20, Nov. 12, 1987, by M. Frick et al., pp. 1237-1245.

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