Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Patent
1988-07-14
1990-09-25
Lee, Mary C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
514548, 514719, 514720, 514729, 514733, 560130, 560138, 560144, 560146, 568645, 568646, 568649, 568650, 568652, 568662, 568764, 568765, 568766, C07C 5742, C07C 69108
Patent
active
049593919
ABSTRACT:
Phenol derivatives of the formula ##STR1## wherein A and B have the same or different meanings and each represent one of the groups --C.tbd.C--, cis--CH.dbd.CH-- or trans--CH.dbd.CH--, R.sub.1 is hydrogen, an optionally substituted alkyl or phenyl group or a cycloalkyl group, R.sub.2 is hydrogen, methyl or ethyl, R.sub.3 represents hydrogen, acetyl or propionyl, R.sub.4 has the same meaning as R.sub.3 or represents an alkyl group, R.sub.5 is a carboxylic or a hydroxy group or a functional derivative of such groups or R.sub.5 is a nitrile group and R.sub.6 is hydrogen, an alkyl group or the group OR.sub.4 which specifically inhibit 5-lipoxygenase and are useful in pharmaceutical compositions for prophylaxis and treatment of diseases due to the action of leukotrienes. The compounds are prepared by reacting suitable acetylene compounds or metal derivatives thereof with alkyl or aryl halides or by means of Wittig reactions optionally followed by transforming the member R.sub.5 into another carboxylic acid derivative. By hydrogenation A and B may be varied within the scope of the definition.
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Kiesewetter Erwin O.
Loschen Gerriet K. H.
Seippl Ulrich G. P.
Vollenberg Werner P.
Winter Werner
Gruenenthal GmbH
Lee Mary C.
Scalzo Catherine
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