Phenol derivatives and pharmaceutical compositions containing th

Details Phenol derivatives and pharmaceutical compositions containing th Phenol derivatives and pharmaceutical compositions containing th

1986-05-13

1988-07-26

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514548, 514719, 514720, 514729, 514733, 560130, 560138, 560144, 560145, 560146, 568609, 568645, 568646, 568649, 568650, 568652, 568662, 568764, 568765, 568766, A61K 3122, A61K 3105, C07C 3908, C07C 4323

Patent

active

047600870

ABSTRACT:
Phenol derivatives of the formula ##STR1## wherein A and B have the same or different meanings and each represent one of the groups --C.tbd.C--, cis--CH.dbd.CH-- or trans--CH.dbd.CH--, R.sub.1 is hydrogen, an optionally substituted alkyl or phenyl group or a cycloalkyl group, R.sub.2 is hydrogen, methyl or ethyl, R.sub.3 represents hydrogen, acetyl or propionyl, R.sub.4 has the same meaning as R.sub.3 or represents an alkyl group, R.sub.5 is a carboxylic or a hydroxy group or a functional derivative of such groups or R.sub.5 is a nitrile group and R.sub.6 is hydrogen, an alkyl group or the group OR.sub.4 which specifically inhibit 5-lipoxygenase and are useful in pharmaceutical compositions for prophylaxis and treatment of diseases due to the action of leukotrienes. The compounds are prepared by reacting suitable acetylene compounds or metal derivatives thereof with alkyl or aryl halides or by means of Wittig reactions optionally followed by transforming the member R.sub.5 into another carboxylic acid derivative. By hydrogenation A and B may be varied within the scope of the definition.

REFERENCES:
patent: 4590304 (1986-05-01), Wallace et al.

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