Phenol derivatives and antitrypanosoma...

Details Phenol derivatives and antitrypanosoma... Phenol derivatives and antitrypanosoma...

2004-10-18

2009-11-24

Seaman, D. Margaret (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C549S476000, C549S478000

Reexamination Certificate

active

07622598

ABSTRACT:
A compound represented by formula (I):[wherein, for example,X is a hydrogen atom or a halogen atom;R1is a hydrogen atom;R2is a hydrogen atom or a C1-4alkyl group;R3is —CHO or —COOH; andR4is —CH═CH—(CH2)p—CH3(wherein p is an integer of 1 to 12), —CH(OH)—(CH2)q—CH3(wherein q is an integer of 1 to 13), —CH(OH)—CH2—CH(CH3)—(CH2)2—CH═C(CH3)2, —CH═CH—CH(CH3)—(CH2)3—CH(CH3)2, —(CH2)2—CH(CH3)—(CH2)3—CH(CH3)2or —(CH2)8—CH3], an optical isomer thereof and a pharmaceutically acceptable salt thereof. These compounds have antitrypanosoma activity, and accordingly are useful as drugs for preventing or treating the diseases caused by trypanosoma.

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J. Med. Chem. 2003, 46, 4113-4123 “Ascochlorin Derivatives as Ligands for Nuclear Hormone Receptors”.
Togashi et al., “Ascochlorin Derivatives as Ligands for Nuclear Hormone Receptors”, Journal of Medicinal Chemistry, 46(19), 4113-4123 CODEN:JMCMAR; ISSN 0022-2623, 2003, XP002397667, pp. 4113-4123.

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