Phenethylamine antigenic conjugates, their preparation, antibodi

Details Phenethylamine antigenic conjugates, their preparation, antibodi Phenethylamine antigenic conjugates, their preparation, antibodi

1974-12-10

1977-04-05

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2601125R, 2601127, 424 12, 424 88, 424177, 424180, 536 1, C07C10352, C07G 700

Patent

active

040161463

ABSTRACT:
Antigenic phenethylamine conjugates are produced by blocking the amine of the phenethylamine hapten with a group, coupling of the phenethylamine to a carrier, and removal of the blocking group. Specific phenethylamines useful in this invention are amphetamine, epinephrine, and norepinephrine. The antigens thus produced can be used to raise antibodies in animal bodies, the antibodies being specific to the phenethylamine compound employed. In particular, this disclosure is directed to blocked phenethylamines for production of antigens and to a process for preparing the antigens.

REFERENCES:
patent: 2372066 (1945-03-01), Fell
patent: 2957808 (1960-10-01), Campbell
patent: 3098693 (1963-07-01), Sheehan
patent: 3704282 (1972-11-01), Spector
Wolman, "The Chemistry of the Amino Group," S. Patai, Ed., Interscience, New York, 1968, p. 672.
Barton, "Protective Groups in Organic Chemistry," J. McOmie, Ed., Plenum Press, London, 1973, p. 50.

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