Phencyclidine conjugates to antigenic proteins and enzymes

Details Phencyclidine conjugates to antigenic proteins and enzymes Phencyclidine conjugates to antigenic proteins and enzymes

1979-01-25

1981-07-28

Wiseman, Thomas G.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Stablizing an enzyme by forming a mixture, an adduct or a...

435 7, 435177, 435190, 260121, 424 12, 23230B, C12N 996, G01N 3354, C07G 700

Patent

active

042810655

ABSTRACT:
Phencylidine, PCP, derivatives having a non-oxo carbonyl functionality linked directly or through a linking group to the phenyl ring are provided for conjugation to antigenic compositions, particularly poly(amino acids), and enzymes. The antigenic conjugates are employed for the production of antibodies, which find particular use in immunoassays for the determination of phencyclidine, while the enzyme conjugate finds use in a homogeneous enzyme immunoassay for the determination of phencyclidine.

REFERENCES:
patent: 3878187 (1975-04-01), Schneider et al.
patent: 3966556 (1976-06-01), Rubenstein et al.
patent: 4065354 (1977-12-01), Ullman et al.
patent: 4067959 (1978-01-01), Bolz
Kalir et al., "The Use of Antiaminophencyclidine Antibodies for Development of a Sensitive Radioimmunoassay," Chem. Abstracts, vol. 85, No. 21, p. 5 (1976), Abs. #153656y.

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