Phenanthridinium derivatives as DNA binding agents

Details Phenanthridinium derivatives as DNA binding agents Phenanthridinium derivatives as DNA binding agents

2011-05-24

2011-05-24

Aulakh, Charanjit S (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S070000

Reexamination Certificate

active

07947703

ABSTRACT:
Disclosed are new classes of phenanthridinium derivatives, most notably dihydro-imidazo-phenanthridinium (DIP) compounds. The compounds are prepared by the reaction of the middle b ring of a phenanthridinium core with primary amines to form the DIP compounds. This reaction can also be applied to other classes of starting compounds which comprise a 6-membered ring aromatic heterocycle having a ring nitrogen and at least one alpha hydrogen atom which can be reacted with a primary amine. Also disclosed is a method of using the DIP compounds for treatment of ovarian cancer.

REFERENCES:
patent: 5401847 (1995-03-01), Glazer et al.
patent: 5783687 (1998-07-01), Glazer et al.
patent: 1 223 226 (2002-07-01), None
patent: WO 95/01341 (1995-01-01), None
patent: WO 96/03384 (1996-02-01), None
CAPLUS Abstract Accession No. 1977:121139 & Comptes Rendus des Seances de l'Academie des Sciences, Serie D: Sciences Naturelles, 283(11): 1365-1367, “DNA intercalating drugs.”
Yamazaki et al., Synthesis in the Diazasteroid Group VIIL Synthetic Studies of the 14,17-Diazasteroid System (1), J. Heterocyclic Chem., 16: 517 (1979).
Preston et al., “Further Investigations of Heterocyclic Alkylating Agents”, J. Org. Chem., 28: 471-480 (1964).
Osbond et al., “Synthesis of Some Glyoxalino (1′ : 2′-1 :2)quinolines”, J. Chem. Soc., 1853-1856 (1950).
Parenty et al., “General One-Pot, Three-Step Methodology Leading to an Extended Class of N-Heterocyclic Cations: . . . ”, J. Org. Chem., 69: 5934-5946 (2004).
Lynch et al., “Synthesis, Biological Activity and Comparative Analysis of DNA Binding Affinities . . . ”, Bioorganic & Medicinal Chemistry Letters, 11: 2643-2646 (2001).
Whittaker et al., “The interaction of DNA-targeted platinum phenanthridinium complexes with DNA”, Nucleic Acids Research, 26(17): 3933-3939 (1998).
Koyama et al,, “Polycyclic N-Hetero Compounds. VI. Synthesis of 11,13,15-Triazasteroidal Compounds . . . ”, Chem. Pharm. Bull., 23(9): 2015-2018 (1975).

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