Phenanthridine derivatives as bradykinin antagonists

Details Phenanthridine derivatives as bradykinin antagonists Phenanthridine derivatives as bradykinin antagonists

2006-12-19

2011-10-11

Shiao, Rei-tsang (Department: 1628)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S285000, C544S359000

Reexamination Certificate

active

08034827

ABSTRACT:
The present invention relates to new phenanthridine derivatives of formula (I), wherein the variables are as defined in the specification, to processes for producing the same, to pharmacological compositions containing the same and to their use in therapy or prevention of painful and inflammatory processes.

REFERENCES:
patent: 4529728 (1985-07-01), Fabre et al.
patent: 7056937 (2006-06-01), Grant et al.
patent: WO 00/75107 (2000-12-01), None
patent: WO 02/76964 (2002-10-01), None
patent: WO 02/99388 (2002-12-01), None
patent: WO 04/54584 (2004-07-01), None
patent: WO 05/04810 (2005-01-01), None
Miura et al., 1998, CAS: 129: 175521.
Bergbreiter et al., “Soluble polymer-supported catalysts containing azo dyes,”Org. Lett., 2002, 4(5):737-740.
Ferreira et al., “Evidence for the participation of kinins in Freund's adjuvant-induced inflammatory and nociceptive responses in kinin B1 and B2 receptor knockout mice,”Neuropharmacol., 2001, 41(8):1006-1012.
Hess et al., “Cloning and pharmacological characterization of a human bradykinin (BK-2) receptor,”Biochem. Biophys. Res. Commun., 1992, 184:260-268.
Leeb-Lundberg et al., “International Union of Pharmacology. XLV. Classification of the Kinin Receptor Family: from Molecular Mechanisms to Pathophysiological Consequences,”Pharmacol. Rev., 2005, 57:27-77.
Ma et al., “Basal expression of bradykinin B(1) receptor in the spinal cord in humans and rats,”Neuroreport, 2001, 12(11):2311-2314.
Ma et al., “Basal expression of bradykinin B1 receptor in peripheral sensory ganglia in the rat,”Neuroreport, 2000, 11(18):4003-4005.
Ma, “The expression of bradykinin B1 receptors on primary sensory neurones that give rise to small caliber sciatic nerve fibres in rats,”Neuroscience, 2001, 107(4):665-673.
Marceau, “A possible common pharmacophore in the non-peptide antagonists of the bradykinin B1 receptor,”Trends in Pharmacological Sciences, 2005, 26(3):116-118.
Menke et al., “Expression cloning of a human B1 bradykinin receptor,”J. Biol. Chem., 1994, 269(34):21583-21586.
Miura et al., “Oxidative Cross-Coupling of N-(2'-Phenylphenyl)benzene- sulfonamides or Benzoic and Naphthoic Acids with Alkenes Using a Palladium-Copper Catalyst System under Air, ”J. Org. Chem., 1998, 63(15):5211-5215.
Pesquero et al., “Hypoalgesia and altered inflammatory responses in mice lacking kinin B1 receptors,”PNAS, 2000, 97(14):8140-8145.
Ransom et al., “Pharmacological characterization and radioligand binding properties of a high-affinity, nonpeptide, bradykinin B1 receptor antagonist,”Eur. J. Pharmacol., 2004, 499:77-84.
Stemp et al., “Design and synthesis of trans-N-[4-{2-(6-cyano- 1,2,3, 4-tetrahydroisoquinolin-2-yl)ethyl}-4-quinolinecarboxamide {SB-277011}: a potent and selective dopamine D3 receptor antagonist with high oral bioavailability and CNS penetration in the rat,”J. Med. Chem., 2000, 43:1878-1885.
Su et al., “Discovery of a Potent, Non-peptide Bradykinin B1 Receptor Antagonist,”J. Am. Chem. Soc., 2003, 125(25):7516-7517.
Uhlmann and Pfleiderer, “Substituted β-Phenyl-ethyl Groups. New Blocking Groups for Oligonucleotide Syntheses by the Phosphotriester Approach,”Helvetica Chimica Acta, 1981, 64(5):1688-1703.
Wood et al., “Benzodiazepines as Potent and Selective Bradykinin B1 Antagonists,”J. Med. Chem., 2003, 46(10):1803-1806.
Wotherspoon and Winter, “Bradykinin B1 receptor is constitutively expressed in the rat sensory nervous system,”Neuroscience Letters, 2000, 294(3):175-178.

Affiliated with

Also associated with

Rating

Phenanthridine derivatives as bradykinin antagonists does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Phenanthridine derivatives as bradykinin antagonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Phenanthridine derivatives as bradykinin antagonists will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4300805