Phenalenimine fluorescent dyes and their use in analytical compo

Details Phenalenimine fluorescent dyes and their use in analytical compo Phenalenimine fluorescent dyes and their use in analytical compo

1991-05-28

1992-10-13

Housel, James C.

Chemical apparatus and process disinfecting, deodorizing, preser

Analyzer, structured indicator, or manipulative laboratory...

Calorimeter

435 75, 435795, 435805, 435 793, 435 794, 435 732, 435 731, 436523, 436533, 436541, 436546, 546285, 546 75, 564270, 252586, 252589, 25230116, C01N 3353

Patent

active

051548879

ABSTRACT:
Certain phenalenimine fluorescent compounds represented by the structure ##STR1## wherein R' and R" are independently hydrogen, alkyl, cycloalkyl, aryl or a heterocycle, or R' comprises the carbon and heteroatoms which form a fused ring with the compound nucleus, are useful in biomedical and analytical determinations. These compounds can be used for staining cells, as well as for the determination of various analytes found in human or animal biological fluids. Such determinations can be carried out in solution or by using dry analytical elements. The fluorescent compounds can be reacted with quinone nuclei to form reducible compounds which are also useful in analytical methods. In addition, the compounds can be incorporated into what are known as "loadable" latex particles to form detectable labels and biological reagents.

REFERENCES:
patent: 3992158 (1976-11-01), Przybylowicz et al.
patent: 4857271 (1989-08-01), Belly et al.
STN-CAS Abstract Accession No.: CA 108(18):158857t--"Spectral characteristics of excitation states of phenalene amino derivative in Ethanol" Aladov, A. V.; Ryl'kov, V. V.; Reznichenko, A. V.; Kokin, V. N.; Opt. Spektrosk., 64(1) (1988) pp. 51-56, Resgistry No. 113702-10-0.
Franz et al, Tetrahedron, 34, pp. 2147-2151 (1978).
Solodar et al, Zh. Orgn. Khim., 16(5), pp. 1062-1064 (1980).

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