Phenacyl-type esters of PGF.sub.2.alpha. and its 15-methyl analo

Details Phenacyl-type esters of PGF.sub.2.alpha. and its 15-methyl analo Phenacyl-type esters of PGF.sub.2.alpha. and its 15-methyl analo

1974-08-14

1982-04-13

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

C07C17700

Patent

active

043249051

ABSTRACT:
Phenacyl-type esters of PGF.sub.2.alpha., 15(S)-15-methyl-PGF.sub.2.alpha., and 15(R)-15-methyl-PGF.sub.2.alpha. are disclosed, represented by the formula ##STR1## wherein M is ##STR2## wherein R.sub.1 is phenyl, p-bromophenyl, p-biphenylyl, p-nitrophenyl, p-benzamidophenyl, or 2-naphthyl; and wherein R.sub.2 is hydrogen or benzoyl. The products are useful for the same pharmacological and medical purposes as the corresponding prostaglandin and analogs, and are also useful as a means for obtaining highly purified products.

REFERENCES:
patent: 3804890 (1974-04-01), Bundy
patent: 3822303 (1974-07-01), Yankee
patent: 3984454 (1976-10-01), Skubulla et al.
Yankee et al., J. Am. Chem. Soc. 94, 3651 (1972).
Fiezer et al., Reagent for Organic Synthesis p. 1201 (1967).
McComie Protective Groups in Organic Chemistry p. 199 (1972).

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