Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters
Patent
1974-08-14
1981-12-08
Gerstl, Robert
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acid esters
C07C17700
Patent
active
043049265
ABSTRACT:
Phenacyl-type esters of PGE.sub.2, PGE.sub.1, and 13,14-dihydro-PGE.sub.1 and their 15-methyl, 16,16-dimethyl, and 17-phenyl analogs, including the respective 15(R)epimers, are disclosed, represented by the formula ##STR1## wherein M is ##STR2## wherein R.sub.3 is hydrogen or methyl; wherein Q is ##STR3## wherein each of R.sub.4 and R.sub.5 is hydrogen or methyl, being the same or different, or ##STR4## wherein the moiety--C.sub.t H.sub.2t -- represents a valence bond or alkylene of one to 10 carbon atoms, inclusive, with one to 7 carbon atoms, inclusive, between ##STR5## and the phenyl ring; wherein R.sub.1 is phenyl, p-bromophenyl, p-biphenylyl, p-nitrophenyl, p-benzamidophenyl, or 2-naphthyl; wherein R.sub.2 is hydrogen or benzoyl; and wherein (a) X is --CH.sub.2 CH.sub.2 -- or trans--CH.dbd.CH-- and Y is --CH.sub.2 CH.sub.2 --, or (b) X is trans--CH.dbd.CH-- and Y is cis--CH.dbd.CH--. The products are useful for the same pharmacological and medical purposes as the corresponding prostaglandins and analogs, and are also useful as a means for obtaining highly purified products.
REFERENCES:
patent: 3812179 (1974-05-01), Bundy
patent: 3984454 (1976-10-01), Skubulla et al.
Shriner et al., Organic Compounds, p. 197 (1950).
Fieser et al., Reagent for Organic Synthesis, p. 1201.
McOmie, Protective Groups in Organic Chemistry, p. 199 (1972).
Gerstl Robert
Nielsen Morris L.
The Upjohn Company
Welch Lawrence T.
LandOfFree
Phenacyl-type esters of PGE-types compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Phenacyl-type esters of PGE-types compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Phenacyl-type esters of PGE-types compounds will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-568852