Phenacyl-type esters of PGA.sub.1 and PGA.sub.2

Details Phenacyl-type esters of PGA.sub.1 and PGA.sub.2 Phenacyl-type esters of PGA.sub.1 and PGA.sub.2

1974-08-14

1978-03-21

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

424317, C07C17700

Patent

active

040805069

ABSTRACT:
Phenacyl-type esters of PGA.sub.1 and PGA.sub.2 are disclosed, represented by the formula ##STR1## wherein R.sub.1 is phenyl, p-bromophenyl, p-biphenylyl, p-nitrophenyl, p-benzamidophenyl, or 2-naphthyl; wherein R.sub.2 is hydrogen or benzoyl; and wherein Y is --CH.sub.2 CH.sub.2 -- or cis--CH.dbd.CH--. The products are useful for the same pharmacological and medical purposes as the corresponding prostaglandins and analogs, and are also useful as a means of obtaining highly purified products.

REFERENCES:
patent: 3729502 (1973-04-01), Beal et al.
patent: 3984454 (1976-10-01), Skubbula
Fiesen et al., Reagents for Organic Synthesis, p. 1201 (1967).
McComie, Protective Groups in Organic Chemistry, p. 199 (1972).

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