Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Ultrasound contrast agent
Patent
1994-01-19
1996-09-24
Dees, Jose G.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Ultrasound contrast agent
A61K 4900
Patent
active
055588530
ABSTRACT:
Agents for enhancing the contrast in a diagnostic ultrasound procedure comprise colloidal dispersions of the liquid-in-liquid type, i.e., emulsions or microemulsions, in which the dispersed liquid phase is a liquid having a boiling point below the temperature of the animal to be imaged and which therefore undergoes a phase change from a dispersed liquid to a highly echogenic dispersed gaseous foam or kugelschaum following administration to the animal. The liquid state of the dispersed phase allows one to manufacture extremely stable, pharmaceutically acceptable emulsions with particle sizes typically below 1000 nm. The gaseous state at body temperature yields highly echogenic microbubbles, typically below 10,000 nm in diameter, which are effective as ultrasound contrast agents. Intravenous, intraarterial, oral, intraperitoneal, and intrauterine dosage forms, methods of administration, and imaging techniques are described.
REFERENCES:
patent: 3898843 (1976-11-01), Chabert et al.
patent: 4265251 (1981-05-01), Tickner
patent: 4276885 (1981-07-01), Tickner et al.
patent: 4442843 (1984-04-01), Rasor et al.
patent: 4466442 (1984-08-01), Hillman et al.
patent: 4533254 (1985-08-01), Cook et al.
patent: 4544545 (1985-10-01), Ryan et al.
patent: 4572203 (1986-02-01), Feinstein
patent: 4657756 (1987-04-01), Rasor et al.
patent: 4681119 (1987-07-01), Rasor et al.
patent: 4684479 (1987-08-01), D'Arrigo
patent: 4718433 (1988-01-01), Feinstein
patent: 4767610 (1988-08-01), Long
patent: 4774958 (1988-10-01), Feinstein
patent: 4832941 (1989-05-01), Berwing et al.
patent: 4844882 (1989-07-01), Widder et al.
patent: 4859363 (1989-08-01), Davis et al.
patent: 4865836 (1989-09-01), Long, Jr.
patent: 4895876 (1990-01-01), Schweighardt et al.
patent: 4900540 (1990-02-01), Ryan et al.
patent: 4927623 (1990-05-01), Long, Jr.
patent: 4957656 (1990-09-01), Cerny et al.
patent: 4987154 (1991-01-01), Long, Jr.
patent: 4993415 (1991-02-01), Long
patent: 5078146 (1992-01-01), Sato
patent: 5080885 (1992-01-01), Long, Jr.
patent: 5088499 (1992-02-01), Unger
patent: 5107842 (1992-04-01), Levene et al.
patent: 5114703 (1992-05-01), Wolf et al.
patent: 5123414 (1992-06-01), Unger
patent: 5137928 (1992-08-01), Erbel et al.
patent: 5141738 (1992-08-01), Rasor et al.
patent: 5147631 (1992-09-01), Glajch et al.
patent: 5155215 (1992-10-01), Ranney
patent: 5171755 (1992-12-01), Kaufman et al.
patent: 5205290 (1993-04-01), Unger
patent: 5260496 (1993-11-01), Meinert et al.
patent: 5271928 (1993-12-01), Schneider et al.
patent: 5281408 (1994-01-01), Unger
patent: 5284645 (1994-02-01), Long
patent: 5344930 (1994-09-01), Riess et al.
patent: 5354549 (1994-10-01), Klaveness et al.
patent: 5385147 (1995-01-01), Anderson et al.
patent: 5393513 (1995-02-01), Long, Jr.
patent: 5401493 (1995-03-01), Lohrmann et al.
patent: 5406950 (1995-04-01), Brandenburger et al.
Grant & Hackh's Chemical Dictionary, p. 36, 1987.
Webster's 9th New Collegiate Dictionary, p. 681, 1986.
G. Serratrice, et al., "Co-solubilisation de fluorocarbures et d'eau en presence de nouveaux tensioactifs non iooniques fluores,"J. Chim. Phys. 87:1969-1980 (1990).
F. Szonyi and A. Cambon, "Syntheses de Tensioactifs F-alkyles non ioniques Monodisperses," J. Fluor. Chem. 36:195-209 (1987).
J. Ophir and K. J. Parker, "Contrast Agents in Diagnostic Ultrasound," Ultrasound in Med. & Biol. 15:319-333 (1989).
A. S. Kabalnov, et al., "Solubility of fluorocarbons in water as a key parameter determining fluorocarbon emulsion stability" J. Flourine Chemistry, 50:271-284 (1990).
H. J. Bleeker, et al., "Ultrasonic characterization of Albunex, a new contrast agent," J. Accoust, Soc. Am. 87(4) (1990).
R. Schlief, "Ultrasound contrast agents," Current Opinion in Radiology 3:198-207 (1991).
H. Bleeker, et al., "On the Application of Ultrasonic Contrast Agents for Blood Flowmetry and Assessment of Cardiac Perfusion," J. Ultrasound Med 9:461-471 (1990).
T. Ohta, et al., "Effect of the Contrast Agent and the Agitation Method on the Size, Number and Stability of Microbubbles: A Basic Experiment for the Myocardial Contrast Study," Jpn J. Med Ultrasonics, 18:318-325 (1991).
S. B. Feinstein, et al., "Myocardial Contrast Echocardiography: Examination of Intracoronary Injections, Microbubble Diameters, and Video-Intensity Decay," Am. J. Physio. Imaging 1:12-18 (1986).
P. L. Davis, et al., "Echogenicity Caused by Stable Microbubbles in a Protein-Lipid Emulsion," Clin. Ultrasound 9:249-252 (1981).
V. F. Fobbe, et al., "Farbkodierte Duplexsonographic and Ultraschallkonstrastmittel--Nachweis von renalen Perfusionsdefekten im Tierexperiment," Fortschr. Rontgenstr. 154.3 242-245 (1991).
M. R. Violante, et al., "Particle-Stabilized Bubbles for Enhanced Organ Ultrasound Imaging," Invest. Radiology 26:194-200 (1991).
Mattrey, R. F., et al., Gas Emulsions as Ultrasound Contrast Agents Preliminary Results in Rabbits and Dogs, Investigative Radiology, 29: S139-S141 (Jun. Supplement 1994).
Meltzer, R. S., et al., Transmission of Ultrasonic Contrast Through the Lungs, Ultrasound in Med. & Biol., vol. 7, No. 4, pp. 377-384 (1981).
Swanson, D. P., et al., Pharmaceuticals in Medical Imaging; Radiopague Contrast Media Radiopharmaceuticals Enhancement Agents for Magnetic Resonance Imaging and Ultrasound, Macmillian Publishing Co., Inc., pp. 682-685 (1990).
Schubert et al., "Microemulsifying fluorinated oils with mixtures of fluorinted and hydrogentated surfactants," Colloids and Surfaces A: Physiochemical and Engineering Aspects 84:97-106 (1994).
Keller et al., "Ultrasound Backscatter Characteristics of Sonicated Echo Contrast Agents," American Heart Association Abstracts, Pt. III, vol. 72, No. 4, p. 1705. (Oct. 1985).
Widder et al., "Microbubbles as a Contrast Agent for Neurosonography and Ultrasound-Guided Catheter Manipulation: In Vitro Studies," AJR, pp. 347-352. (Aug. 1985).
Keller et al., "Sucessful Left Ventricular Opacification Following Peripheral Venous Injection of Sonicated Contrast Agent: An Experimental Evaluation," American Heart Jouranl, vol. 115, No. 4, pp. 570-575. (Sep. 1987).
English Translation by Nissin Marshall, Encyclopedia Des Gaz (Gas Encyclopedia). (1976).
Ziskin, et al., "Contrast Agents for Diagnostic Ultrasound," Investigative Radiology, vol. 7, No. 6, pp. 500-505. (Nov.-Dec. 1972).
Feinstein, et al., "Safety and Efficacy of a New Transpulmonary Ultrasound Contrast Agent: Initial Multicancer Clinical Results," JACC, vol. 16, No. 2, pp. 316-324. (Aug. 1990).
Epstein, et al., "On the Stability of Gas Bubbles in Liquid-Gas Solutions," The Journal of Chemical Physics, vol. 18 No. 11, pp. 1505-1509. (Nov. 1950).
Meltzer, et al., "Why Do the Lungs Clear Ultrasonic Contrast?" Ultrasound in Medicine and Biology, vol. 6, No. 3, pp. 263-269. (1980).
N. de Jong, et al., Ultrasonics 1991, vol. 29, Jul. pp. 324-330 "Principles and Recent Developments in Ultrasond Contrast Agents".
N. de Jong et al. Ultrasonics 1992, vol. 30 No. 2.pp. 95-103 "Absorption and Scatter of Encapsulated Gas Filled Microspheres: Theoretical Considerations and Some Measurments".
Journal of Clinical & Laboratory Research Investigative Radiology, "Proceedings of The Association of University Radiologists Annual Meeting 1982", Jul.-Aug. 1982, vol. 17, No. 4, p. S28.
Mattrey et al., "Perfluoroctylbromide: A Liver/Spleen-Specific and Tumor-Imaging Ultrasound Contrast Material", Radiology 145:759-762, Dec. 1982.
Long, Jr. et al., "Experiments with Radiopague Perflurorcarbons Emulsions for Selective Opacification of Organs and Total Body Angiography", Investigative Radiology, May.-Jun. 1980, vol. 15, pp. 242-247.
Zarif et al., "Synergistic Stabilization of Perfluorocarbon-Pluronic F-68 Emulsion by Perfluoroalkylated Polyhydroxylated Surfactants", JAOCS, vol. 66, No. 10 (Oct. 1989).
Varescon et al., "An Easy, Convenient Way of Describing the Stability of Fluorocarbon Emulsions", Journal de chimie physique, 1989, 86, n .degree. 10, pp. 2111-2116.
Handa et al., "Phospholipid Monolayers at the Triolein-Saline Interface: Production of Microemulsion Particles and Conversion of Monolayers to Bilayers", Biochemistry 1990, 29, p
Bengtsson W. Patrick
Cebulak Mary C.
Dees Jos,e G.
Sonus Pharmaceuticals
LandOfFree
Phase shift colloids as ultrasound contrast agents does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Phase shift colloids as ultrasound contrast agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Phase shift colloids as ultrasound contrast agents will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1927089