Phase separation-microencapsulated pharmaceuticals compositions

Details Phase separation-microencapsulated pharmaceuticals compositions Phase separation-microencapsulated pharmaceuticals compositions

1990-11-26

1996-03-19

Russel, Jeffrey E.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

424426, 424435, 514900, 514902, A61K 600, A61K 914, A61K 950, A61K 4730

Patent

active

055002285

ABSTRACT:
Oral compositions for the local administration of a therapeutic agent to a periodontal pocket of a patient for alleviating dental disease comprise a plurality of dry, discrete microparticles each of which comprise an effective amount of at least one therapeutic agent dispersed in a matrix comprising a biocompatible and biodegradable polymer of preferably, the dry microparticles and dispersed into the periodontal pocket whereby upon contact with the moist environment of the pocket, they hydrate, become tacky and adhere to one another and to the tissues surrounding the pocket so as to maintain intimate contact with the involved tissue so as to induce long term therapeutic benefits.

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