X-ray or gamma ray systems or devices – Electronic circuit – With display or signaling
Reexamination Certificate
1999-09-13
2001-05-01
Bruce, David V. (Department: 2882)
X-ray or gamma ray systems or devices
Electronic circuit
With display or signaling
C378S098110, C378S098120
Reexamination Certificate
active
06226353
ABSTRACT:
FIELD OF THE INVENTION
This invention relates generally to the observation of structural features of objects utilising penetrating radiation such as x-rays. In particular, the invention relates to the derivation of images of the phase change introduced by an object in penetrating radiation incident on the object, from a two-dimensional intensity record of the penetrating radiation after it has traversed the object. The invention may be extended to retrieve separate phase and absorption data from a set of radiographic measurements.
BACKGROUND ART
The present applicant's international patent publications WO 95/05725 (PCT/AU94/00480) and WO 96/31098 (PCT/AU96/00178) disclose various configurations and conditions suitable for differential phase-contrast imaging using hard x-rays. Other earlier disclosures of interest are to be found in Soviet patent 1402871 and in U.S. Pat. No. 5,319,694. Differential phase-contrast imaging shows great promise for viewing the internal structure of objects for which traditional absorption-contrast radiography is of limited or no value because of very weak absorption contrast. This is the case, for example, with soft tissue within the human body.
The practical issue optimally and efficiently deriving the phase-contrast image for an object from the actual record at the detector is addressed in two related papers by Nugent et al
Phys. Rev. Lett.
77, 2961-2964 (1996);
J. Opt. Soc. Am. A
13. 1670-82 (1996) and references therein. In these papers, it has been demonstrated that with monochromatic plane-wave x-radiation as in the configurations of WO 95/05725 and U.S. Pat. No. 5,319,694, the retrieval of phase information from measurement of the propagation of intensity can be used on treating the propagation of the modified radiation field whose characteristics reflect the phase modifying effects of the object. A two-dimensional recording of the intensity of the penetrating radiation after it has traversed the object is the result of variations in the local direction of propagation of the radiation arising from variations in local refractive index, typically an indication of a boundary or rapid variation in electron density within the object or of a thickness variation. The aforementioned articles by Nugent et al utilise a treatment of the propagation of a plane monochromatic electromagnetic wave on Maxwell's equations to derive a transport-of-intensity equation and propose solutions of this equation to derive a phase-contrast image from the intensity record. These suggested solutions to the transport-of-intensity equation involve expanding the phase in orthogonal functions. The kind of function chosen depends on the shape of the sample, and thus Zernike polynomials are adequate for a circular shape whilst a Fourier expansion is most suitable for a square-shaped sample.
The aforementioned international patent application WO 96/31098 discloses an in-line phase-contrast imaging configuration utilising a substantially point source and a two-dimensional x-ray imaging detector spaced from the object. It is demonstrated in the application that, in contrast to previous phase-contrast imaging configurations, a point source may be utilised, and moreover that the source may be broadly polychromatic provided its radiation has high lateral spatial coherence, which in practical terms indicates a maximum source diameter (s) dependent upon the source to object distance (R
1
). The larger the source-object distance or the smaller the source size, the greater the lateral spatial coherence (see Wilkins et al
Nature
384 335-8 (1996). A consequence of these disclosures in WO 96/31098 is that the approach proposed is more closely related to traditional methods used for absorption-contrast radiography and should be easier to implement than earlier proposals. This method of phase-contrast imaging is especially advantageous in the hard x-ray region where the lack of suitable lens elements make other techniques conventionally used in visible light and soft x-ray microscopy unsuitable.
It is an object of the present invention, at least in one or more embodiments, to provide a method of obtaining a phase-contrast image from a two-dimensional intensity record where the penetrating radiation substantially emanates from a point-like source. In one or more embodiments, it is a particular objective to provide a method adaptable to the extraction of phase and absorption-contrast information from radiographic images recorded with a microfocus source which need not be highly monochromatic.
SUMMARY OF THE INVENTION
In certain aspects, the invention involves the concept of obtaining two or more intensity records at a common finite distance after the radiation has emerged from the object, for respective different energy distributions of the radiation.
In one or more other aspects, the invention entails an appreciation that, with certain features, a point-like source configuration also lends itself to an approach based on the solution of a differential transport-of-intensity equation, albeit a different one from that used by others for the plane-wave case.
The invention is especially useful for separating out and retrieving phase information from a typical intensity record (obtained with a microfocus radiation source) which has both phase-contrast and absorption-contrast content.
In a first aspect, the invention provides method of obtaining an image of the phase change introduced by an object in penetrating radiation incident on the object, including:
irradiating the object with penetrating radiation having high lateral spatial coherence;
receiving at least a portion of said radiation at detector means after the radiation has emerged from the object and thereby obtaining and storing at least two intensity records for the received radiation each including intensity values at predetermined intervals; and
utilising these values to derive a grid of values defining an image of the phase change introduced by the object in the penetrating radiation:
wherein said intensity records are obtained at a uniform finite distance after the radiation has emerged from the object, and are for respective different energy distributions of the detected radiation.
In its first aspect, the invention further provides apparatus for obtaining an image of the phase change introduced by an object in penetrating radiation incident on the object, including:
means to provide a source for irradiating an object with penetrating radiation having high lateral spatial coherence; and
detector means for receiving at least a portion of said radiation after the radiation has emerged from the object whereby to generate at least two intensity records for the received radiation each including intensity values at predetermined intervals;
wherein said detector means is arranged for obtaining said intensity records at a uniform finite distance after the radiation has emerged from the object, and energy charactersing means is provided whereby said intensity records are for respective different energy distributions of the detected radiation.
In one embodiment, the respective different energy distributions are obtained by altering the energy spectrum of the radiation irradiating the object. This might be achieved, for example, by modifying the output of the radiation source, or by pre-filter means. In another embodiment, the respective different energy distributions are obtained by providing for the detector means to provide intensity as a function of energy in a certain energy band or band(s). For this purpose, a two-dimensional detector means may be variably wavelength sensitive, or be preceded by a variable filter shutter means. Further alternatively, the image intensity may be recorded as a function of photon energy for each pixel over a number of ranges of x-ray energy. Advantageously, for enhanced resolution, multiple intensity records may be obtained for respective multiple energy distributions of the radiation.
In the simplest case, each energy distribution may be a particular wavelength or photon energy level.
The afor
Gureyev Timur
Pogany Peter Andrew
Stevenson Andrew Wesley
Wilkins Stephen William
Bruce David V.
Fulwider Patton Lee & Utecht LLP
Ho Allen C.
X-Ray Technologies Pty Ltd
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