Phase modulation spectroscopic system

Details Phase modulation spectroscopic system Phase modulation spectroscopic system

1991-01-22

1993-02-16

Teska, Kevin J.

Boots, shoes, and leggings

128633, 36441309, G06F 1500, A61B 500

Patent

active

051876728

ABSTRACT:
A phase modulated spectroscopy (PMS) system for detecting a pathophysiological condition in a subject includes two laser diodes emitting radiation at wavelengths of about 754-760 nm and 816-840 nm. These two laser diodes are modulated sinusoidally at about 220 MHz. The signals from each laser diode are brought to the subject by a bifurcated plastic optical fiber of 1 mm diameter. After transmission through the subject, the signals are detected by a Hamamatsu R928 photomultiplier (PMT), which generates two experimental signals. The experimental signals are compared to a reference signal in a phase detector. The respective phase shifts experienced by the signals are combined to form sum and difference signals, which are correlated to a pathophysiological condition.

REFERENCES:
patent: 4138727 (1979-02-01), Mantz
patent: 4714341 (1987-12-01), Hamaguri et al.
patent: 4800495 (1989-01-01), Smith
patent: 4800885 (1989-01-01), Johnson
patent: 4824242 (1989-04-01), Frick et al.
patent: 4846183 (1989-07-01), Martin
patent: 4908762 (1990-03-01), Suzuki et al.
patent: 4972331 (1990-11-01), Chance
Lackowicz, J. R., "Gigahertz Frequency-Domain Fluorometry: Resolution of Complex Intensity Decays, Picosecond Processes and Future Developments" Photon Migration in Tissues, Academic Press/N.Y., pp. 169-186 (1989).
Chance, B. et al., (1988) Proc. Natl. Acad. Sci. USA 85, pp. 4971-4975.
Chance, B. (Ed), "Photon Migration in Muscles and Brain," in Photon Migration in Tissues, Academic Press/New York, pp. 121-135 (1989).
Chance, B. (1951) Rev. Sci. Instrum. 22, 619-627.
Chance, B. (1966) Biochemistry of Copper, ed. Peisach, J. (Academic, New York), pp. 293-303.
Chance, B., Legallais, V. and Schoener, B. (1962) Nature (London) 195, 1073-1075.
Chance, B. (1954) Science 120, 767-775.
Chance, B. (1959) J. Biol. Chem. 234, 3036-3040.
Jobsis-VanderVlient, F. F. (1985) Adv. Exp. Med. Biol. 191, 833-842.
Jobis, F. F. et al., (1977) J. Appl. Physiol. 113, 858-872.
Rosenthal, M. et al., (1976) Brain Res. 108, 143-154.
vanderZee, P. et al. (1988) in Oxygen Transport to Tissue X, eds. Mochizuki, M. et al. (Plenum, New York) pp. 191-197.
Tamura, M. H. et al., (1987) in Chemoreceptors and Reflexes in Breathing, ed. Lahiri, S. (Oxford, N.Y.) in press.
Duysens, L. (1964) Prog. Biophys. Mol. Biol. 14, 1-104.
Chance, B. (1952) Nature (London) 169, 215-230.
Blumberg, W. E. (1987) Biophys. J. 51, 288 (abstr.).
Bonner, R. F. et al., (1987) J. Opt. Soc. Am. Sec. A 4, 423-432.
Galeotti et al. (Eds.), Membrane in Cancer Cells, 551 N.Y. Acad. Sci. (1988) (preface).

Affiliated with

Also associated with

Rating

Phase modulation spectroscopic system does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Phase modulation spectroscopic system, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Phase modulation spectroscopic system will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2152838