Pharmacologically active pyrrolodiazepines

Details Pharmacologically active pyrrolodiazepines Pharmacologically active pyrrolodiazepines

1975-03-17

1977-05-10

Daus, Donald G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26032647, 26032631, 2603265J, 2603265L, 424274, C07D48704

Patent

active

040227669

ABSTRACT:
Compounds of the following formula ##STR1## wherein R is hydrogen, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec.-butyl or tert.-butyl; R.sub.1 is hydrogen, methyl, ethyl or phenyl; R.sub.2 is hydrogen, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec.-butyl or tert.-butyl; R.sub.3 is hydrogen, methoxy, trifluoromethyl, chloro, bromo or fluoro; and R.sub.4 is methyl. The new compounds are useful as CNS depressants, anticonvulsants, anti-inflammatories and inhibitors of the enzymes which promote the synthesis of prostaglandins.

REFERENCES:
patent: 3202699 (1965-08-01), Stempel
patent: 3534021 (1970-10-01), Derieg
patent: 3682892 (1972-08-01), Ning et al.
patent: 3764688 (1973-10-01), Swett
Littell et al.; J. Med. Chem.; vol. 8; p. 722 (1965).
Nakanishi et al.; J. Med. Chem.; vol. 16; pp. 214-219 (1973).
Hromatka et al.; Monatsh fur Chemie; vol. 104; p. 704 (1973).

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