Pharmacologically active pyridine derivatives

Details Pharmacologically active pyridine derivatives Pharmacologically active pyridine derivatives

1973-12-18

1976-06-15

Killos, Paul J.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602472A, 2602475R, 260268DK, 26029356, 2603265R, 260465D, 260465E, 2605705P, 2605705C, 424267, C07D29500

Patent

active

039637298

ABSTRACT:
3-Phenyl-3-aminoalkyl-2,6-dioxo-tetra and hexahydropyridines which are substituted in at least one of the 4 and 5 positions of the hydrogenated pyridine ring by a C.sub.1 -C.sub.4 alkyl group or by a divalent radical which together with at least one of the carbon atoms at said 4 and 5 positions forms a carbocyclic ring of 3 to 8 carbon atoms are novel compounds having pharmacological, in particular central nervous system, especially anti-depressant activity. Alkyl esters, dialkylamides and heterocyclic amides of 4-amino-alkyl-4-cyano-4-phenyl-butanoic and but-2-enoic acids substituted in at least one of the 2 and 3 positions by a C.sub.1 -C.sub.4 alkyl group or by a divalent alkylene radical which together with at least one of the carbon atoms at said 2 and 3 positions forms a carbocyclic ring of 3 to 8 carbon atoms are novel intermediates involved in the preparation of the said pharmacologically active compounds. Several methods are disclosed for preparing the pharmacologically active compounds.

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