Pharmacologically active propanoic acid derivatives

Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal

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260469, 260471R, 260473A, 260473R, 260470R, 260487, 260488CD, 260520B, 424308, 424317, C07C 6522, C07C 6520, C07C 6514

Patent

active

040001890

ABSTRACT:
The invention provides styryl cyclopentenyl propanoic acids and derivatives thereof having spasmolytic activity coupled with low toxicity. Also provided is a method of preparing styryl cyclopentenyl propanoic acid compounds which involves cyclising 7-hydroxy-5,8-dioxo-10-phenyldec-9-enoic acid in the presence of a base.

REFERENCES:
patent: 3649678 (1972-03-01), Fusco et al.
patent: 3732267 (1973-05-01), Miyano
patent: 3875214 (1975-04-01), Schneider
patent: 3888905 (1975-06-01), Miyano
Iesen et al., Reagents for Organic Synthesis, pp. 142-143 (1967).

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