Pharmacologically active piperidine derivatives and their use

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514307, 514319, 544283, 546139, 546205, 546146, A61K 31505, C07D40106

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active

046650768

ABSTRACT:
The piperidine derivatives of formula: ##STR1## in which X denotes --CO--, --CHOH-- or --CH(NH.sub.2)-- and Ar denotes ##STR2## in which R denotes hydrogen or alkyl of 1 to 4 carbon atoms, and Y and Z, which may be identical or different, each denote a hydrogen atom or alkoxy of 1 to 3 carbon atoms, and their addition salts with pharmaceutically acceptable inorganic or organic acids are useful for treating and/or preventing disturbances of cardiac rhythm. These compounds are new except when X is --CO-- and Ar is 1-naphthyl or 1-isoquinolyl.

REFERENCES:
patent: 3149116 (1964-09-01), Binder et al.
patent: 3795677 (1974-03-01), Carr et al.
patent: 3857847 (1974-12-01), Gutzwiller et al.
patent: 4246268 (1981-01-01), Carr
Clemo et al., J. Chem. Soc. 1954 Part III pp. 95-99.
Rubtsov et al. Chem. Abs. 1955 49 332c.

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