Pharmacologically active piperazino derivatives

Details Pharmacologically active piperazino derivatives Pharmacologically active piperazino derivatives

1985-07-18

1990-07-10

Shen, Cecilia

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544367, 544368, 544370, 544372, 544377, 544382, 544383, 544386, 544390, 544391, 544392, C07D48704, C07D29510, C07D29522

Patent

active

049407937

ABSTRACT:
New piperazino derivatives of formula ##STR1## in which R is a phenyl radical substituted with at least one sulphonamido group or a substituted nitrogenated heterocyclic ring, and A is CO, CH.sub.2, SO.sub.2, possessing inhibiting activity towards carbonic anhydrase.
The new products are prepared from compounds of formula R-A-X in which X is OH, SH, halogen, OR"" or SR"" in which R"" is methyl, ethyl, phenyl, carbomethoxy, carboethoxy, and from a piperazino derivative of formula ##STR2## The R' group can also be introduced on termination of the reaction, by removing and substituting a protective group present at the nitrogen.

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"Pharmazeutische Chemie", E. Schroder et al, 1982, p. 754, Georg Thieme Verlag Stuttgart, New York (partial translation attached).
"Arzneimittel Wirkungen", E. Mutschler, 1981, p. 484, Wissenschaftliche Verlagsgessellschaft mbH Stuttgart (partial translation attached).
Carter et al, Biology and Chemistry of the Carbonic Anhydrases, vol. 429, Jun. 29, 1984, Contents.
Botre et al, Journal of Medicinal Chemistry, 1986, 29,1814.
Liebenow et al., Chem. Abst. 90-103673j.
Liebenow et al., Chem. Abst. 84-4696p.
Buyer, Medicinal Chemistry, 2nd Edition, 1960, pp. 800-803.
In re Weber, 198 USPO 328.

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