Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1986-07-30
1988-12-13
Meyers, Albert T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 3135
Patent
active
047911360
ABSTRACT:
Use of compounds of formula (I) ##STR1## to provide a more effective delivery of oxygen to the tissues of a mammalian, including human, recipient.
In vivo applications include the relief or amelioration of conditions wherein there is tissue hypoxia; in vitro the compounds are of use in the storage of mammalian, including human, red blood cells to maintain their oxygen-delivery capacity and prolong their useful storage life.
Also provided is a sterile, sealed vessel containing an anticoagulant, a non-toxic amount of a compound of formula (I) and optionally mammalian, in particular human, red blood cells.
REFERENCES:
patent: 3706768 (1972-12-01), Bays
patent: 3755319 (1973-08-01), Bays
patent: 4591600 (1986-05-01), Creuzet et al.
Assem et al., British Medical Journal, 1974, 2, 93-95.
Chemical Abstracts 81:33553h (1974).
Pfister et al., Journal of Medicinal Chemistry, 1972, 15, 10, 1032-1035.
Batchelor John F.
Hyde Richard M.
Livingstone David J.
Brown Donald
Burroughs Wellcome Co.
Kilcoyne John M.
Meyers Albert T.
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