Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ketone doai
Patent
1987-11-27
1990-10-16
Friedman, Stanley J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ketone doai
A61K 3112
Patent
active
049635905
ABSTRACT:
Pharmacologically active catechol derivatives of formula I ##STR1## wherein R.sub.1 and R.sub.2 independently comprise hydrogen, alkyl, acyl, optionally substituted aroyl, lower alkylsulfonyl or alkylcabamoyl or taken together form a lower alkylidene or cycloalkylidene, X comprises an electronegative substituent such as halogen, nitro, cyano, lower alkylsulfonyl, sulfonamido, aldehyde, caboxyl or trifluoromethyl and R.sub.3 comprises hydrogen, halogen, hydroxy alkyl, amino, nitro, cyano, trifluoromethyl, lower alkylsulfonyl, sulfonamide, aldehyde, alkyl carbonyl, aralkylidene carbonyl or carboxyl or a group selected from ##STR2## wherein R.sub.4 comprises hydrogen, alkyl, cyano, carboxyl or acyl and R.sub.5 comprises hydrogen, cyano, carboxyl, alkoxycarbonyl, carboxyalkenyl, nitro, acyl, optionally substituted aroyl or heteroaroyl, hydroxyalkyl or carboxyalkyl or R.sub.4 and R.sub.5 together form a five to seven membered substituted cycloalkanone ring;
REFERENCES:
Chemical Abstracts, vol. 79, 105449n.
Chemical Abstracts, vol. 104, 109112e.
Chemical Abstracts, vol. 95, 42542v.
Chemical Abstracts, vol. 92, 146461x.
Chemical Abstracts, vol. 79, 27554b.
Merck Index--Ninth Edition.
Backstrom Reijo J.
Heinola Kalevi E.
Honkanen Erkki J.
Kaakkola Seppo K.
Kairisalo Pekka J.
Friedman Stanley J.
Orion-yhtyma Oy
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