Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...
Patent
1977-05-05
1978-08-15
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Parasitic organism or component thereof or substance...
548336, A61K 31415, C07D23364
Patent
active
041073193
ABSTRACT:
The compounds are N-(heterocyclomethylthioalkyl)derivatives of alkylguanidines, C-alkyl and C-aryl amidines and S-alkylisothioureas. The compounds may also have N'-lower alkyl or N'-(heterocyclomethylthioalkyl)substituents. Three compounds of the invention are S-methyl-N-[2-(5-methyl-4-imidazolylmethylthio)ethyl]isothiourea, N,N'-bis-[2-(5-methyl-4-imidazolylmethylthio)ethyl]acetamidine, N,N'-bis-[2-(5-methyl-4-imidazolylmethylthio)ethyl]N"-methylguanidine. The compounds of this invention are histamine H.sub.2 -antagonists.
REFERENCES:
patent: 3734924 (1973-05-01), Black et al.
patent: 3736331 (1973-05-01), Black et al.
patent: 3950333 (1976-04-01), Durant et al.
patent: 3979398 (1976-09-01), White
patent: 4025527 (1977-05-01), Durant et al.
Derwent Abstract 19437v of Belgium patent 804,144 (patent published 2-1974).
Derwent Abstract 19438v of Belgium patent 804,145 (patent published 2-1974).
Derwent Abstract 03751w of Belgium patent 816,850 (patent published 12-1974).
Durant Graham John
Ganellin Charon Robin
Young Rodney Christopher
Edgerton William H.
Foggio Richard D.
Keps Joan S.
Raymond Richard L.
Smith Kline & French Laboratories Limited
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