Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases
Patent
1983-04-05
1985-03-26
Shapiro, Lionel M.
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Hydrolases
435188, 435212, 435216, 435217, A61K 3748, C12N 996, C12N 948, C12N 970, C12N 968
Patent
active
045072833
ABSTRACT:
A derivative of streptokinase-human plasminogen activator complex, in which the active catalytic site essential for fibrinolytic activity is blocked by a 2- or 4-aminobenzoyl group, is useful in treating venous thrombosis.
The blocking group is removable by hydrolysis such that the first order rate is in the range 0.7.times.10.sup.-5 sec.sup.-1 to 2.5.times.10.sup.-5 sec.sup.-1 in isotonic aqueous media at pH 7.4 at 37.degree. C.
REFERENCES:
patent: 4285932 (1981-08-01), Smith
Chem. Abstracts, vol. 71, No. 3, (1969), p. 30, No. 9835z.
Chem. Abstracts, vol. 75, No. 3, (1971), p. 50, No. 1543u.
Chem. Abstracts, vol. 82, No. 17, (1975), p. 93, No. 10697c.
Beecham Group p.l.c.
Shapiro Lionel M.
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