Pharmacologically active compounds

Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases

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435188, 435212, 435216, 435217, A61K 3748, C12N 996, C12N 948, C12N 970, C12N 968

Patent

active

045072833

ABSTRACT:
A derivative of streptokinase-human plasminogen activator complex, in which the active catalytic site essential for fibrinolytic activity is blocked by a 2- or 4-aminobenzoyl group, is useful in treating venous thrombosis.
The blocking group is removable by hydrolysis such that the first order rate is in the range 0.7.times.10.sup.-5 sec.sup.-1 to 2.5.times.10.sup.-5 sec.sup.-1 in isotonic aqueous media at pH 7.4 at 37.degree. C.

REFERENCES:
patent: 4285932 (1981-08-01), Smith
Chem. Abstracts, vol. 71, No. 3, (1969), p. 30, No. 9835z.
Chem. Abstracts, vol. 75, No. 3, (1971), p. 50, No. 1543u.
Chem. Abstracts, vol. 82, No. 17, (1975), p. 93, No. 10697c.

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