Organic compounds -- part of the class 532-570 series – Organic compounds – Nitriles
Patent
1993-09-16
1995-08-29
Haley, Jacqueline
Organic compounds -- part of the class 532-570 series
Organic compounds
Nitriles
558404, 558414, 564166, 564167, 564169, 560136, C07C20522, C07C25550
Patent
active
054461944
ABSTRACT:
A compound according to formula 1 ##STR1## wherein R.sub.1 and R.sub.2 independently represent hydrogen, carbamoyl which is substituted by an alkyl of 1 to 4 carbon atoms, alkylcarbonyl of 2 to 5 carbon atoms or phenyl carbonyl, X represents halogen nitro or cyano and R.sub.3 represents ##STR2## wherein R.sub.4 represents cyano or alkylcarbonyl of 2 to 5 carbon atoms and R.sub.5 represents carbamoyl which is unsubstituted or substituted with alkyl of 1 to 8 carbon atoms or which is substituted with hydroxyalkyl of 1 to 8 carbon atoms or pharmaceutically acceptable esters and salts thereof, and a pharmaceutically acceptable carrier therefor, as well as pharmaceutical compositions containing said compounds as COMT inhibitors.
REFERENCES:
patent: 3278448 (1966-10-01), Lauerer et al.
patent: 3804904 (1974-04-01), Bentley et al.
patent: 3886285 (1975-05-01), Bentley et al.
Chemical Abstracts, vol. 48, (1954) 5831g, Favre.
Chemical Abstracts, vol. 75, (1971), p. 308 (15162h), Kametani et al.
Chemical Abstracts, vol. 78, (1973), p. 471 (29377z), Sa et al.
Chemical Abstracts, vol. 96, (1982), 81807a, Borchardt et al.
Chemical Abstracts, vol. 102, (1985), p. 580 (62028y), Mali et al.
Chemical Abstracts, vol. 104, 207624t, Creveling et al. (1987).
Chemical Abstracts, vol. 79, 105449n, Iida et al. (1973).
Chemical Abstracts, vol. 104, 109112e, Castello et al. (1987).
Chemical Abstracts, vol. 95, 42542v, Vellaccio et al. (1981).
Chemical Abstracts, vol. 92, 146461x, Umemura et al. (1980).
Chemical Abstracts, vol. 79, 27554b, Firnau et al. (1973).
Chemical Abstracts, vol. 88, 98623v, Poluektova et al. (1978).
Chemical Abstracts, vol. 103, 148137r, Pekka Hakkinen. (1985).
Chemical Abstracts, vol. 69, 54785c, Lindberg et al. (1968).
Chemical Abstracts, vol. 75, 151626h, Kametani et al. (1971).
1967-1971--Formula Index, p. 2399F, Column 2, third and fourth lines from the bottom, Chemical Abstracts.
Merck Index, Ninth ed., 1976, p. 1022, No. 7678 and 7679, Merck & Co. Rahway, N.J.
Backstrom Reijo J.
Heinola Kalevi E.
Honkanen Erkki J.
Kaakkola Seppo K.
Kairisalo Pekka J.
Haley Jacqueline
Orion-yhtyma Oy
LandOfFree
Pharmacologically active catechol derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Pharmacologically active catechol derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pharmacologically active catechol derivatives will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1820533