Pharmacologically active biphosphonates, process for the prepara

Details Pharmacologically active biphosphonates, process for the prepara Pharmacologically active biphosphonates, process for the prepara

1984-06-08

1986-11-04

Meyers, Albert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

A61K 3166

Patent

active

046210776

ABSTRACT:
Biphosphonic acids of general formula I: ##STR1## in which R is a fluorine atom of a linear or branched alkyl radical containing between 1 and 5 carbon atoms, which may also be substituted by one or more amino groups of fluorine atoms or both amino groups and fluorine atoms, R' is hydroxy or fluorine, and their salts with an alkali metal, an organic base or a basic aminoacid, exhibit valuable properties in the treatment of urolithiasis or in the treatment as inhibitors of bone reabsorption. The compound 4-amino-1-hydroxybutan-1,1-biphosphonic acid is between 100 and 300 times more active than Cl.sub.2 MDP.

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Chem. Abstract 100:175062g.
Chem. Abstract 88:170246u.
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