Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1993-01-14
1994-11-01
Fay, Zohreh
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514323, 514397, 514538, 514642, 514912, A61K 3155, A61K 31445, A61K 31415
Patent
active
053608011
ABSTRACT:
A method of inducing axial elongation of an eye of an animal comprising contacting a first open animal eye with a cholinergic agonist, detecting the change in axial growth of the first eye, applying a known control agent in a second open animal eye, observing the results of the control agent on the second eye, and comparing the change in axial growth of the first eye with the change in axial growth of the second eye.
REFERENCES:
patent: 5122522 (1992-06-01), Laties et al.
BioSis Abstract of Annals of ophthamology 20(4) 1988. 133-135.
Weisel & Raviola, "Myopia and Eye Enlargement After Neonatal Lid Fusion in Monkeys", Nature 266:66-68.
Schaeffel, F., et al., "Mathematical model of emmetropization in the chicken," J. Optical Soc. of America, 5:2080-2086 (1988).
Taylor, Palmer, "Cholinergic Agonists." Pharmaceutical Basis of Therapeutics, Ed. Goodman and Gilman. New York: 7th Ed. Macmillan Publ., 1985.
Buckley et al., "Antagonist Binding Properties of Five Cloned Muscarinic Receptors Expressed in CHO-K1 Cells," Molecular Pharmacology, 35:469-476 (1989).
Eltze, M., "Muscarinic M.sub.1 -- and M.sub.2 --receptors mediating opposite effects on neuromuscular transmission in rabbit vas deferens," European J. of Pharm., 151:205-211 (1988).
Micheletti, R, and Schiavone, A., "Functional Determination of McN-A-343 Affinity for M.sub.1 Muscarinic Receptors," Journal of Pharmacology and Experimental Therapeutics, 253:310-314 (1990).
McBrien, Neville A., et al., "Atropine Reduces Experimental Myopia and Eye Enlargement Via a Nonaccommodative Mechanism," Investigative Ophthalmology & Visual Science, 34:205-215 (1993).
Laties Alan M.
Stone Richard A.
Fay Zohreh
The Trustees of the University of Pennsylvania
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