Pharmacological composition for topical administration

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes

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Details

424401, 264 41, 264 43, 514944, 514969, A61K 9127, A61K 700

Patent

active

056861028

ABSTRACT:
The invention relates to pharmaceutical compositions which are incorporated into the skin with the aid of novel microaggregates as carriers. The object of the invention is to make available pharmacological active compounds in a biologically and chemically inert carrier for therapeutic and diagnostic administration to the skin or for systemic administration, and in this way to make deeper penetration into the skin or transdermal transport possible. According to the invention, this is effected by means of a pharmaceutical composition for topical administration, which contains asymmetric lamellar aggregates, consisting of phospholipids, pharmacological active compounds and fluorocarbons or fluorocarbon mixtures, the proportion of fluorocarbon being in the range from 1 to 100% weight/volume, in a pharmaceutical excipient which is suitable for topical administration. Preparation is effected by emulsification of the appropriate constituents and use in ointments, creams, lotions, pastes, gels, powders or on a dressing or plaster or by means of a spray.

REFERENCES:
patent: 5061484 (1991-10-01), Heldebrant
patent: 5204112 (1993-04-01), Hope
patent: 5219538 (1993-06-01), Henderson
Lautenschlager in Cosmetics & Toiletries 105, May 1990.
WO 91/00110, publ. Jan. 10, 1991.
WO 89/00848, publ. Feb. 9, 1989.
WO 89/08459, publ. Sep. 21, 1989 See US 5,061,484 Above.

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