Pharmaco-gene delivery in human breast cancer cells

Details Pharmaco-gene delivery in human breast cancer cells Pharmaco-gene delivery in human breast cancer cells

1997-11-03

1999-10-05

Degen, Nancy

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 232, 536 235, 536 2372, 540 2, C12N 1512, C12N 1533, C07J 100

Patent

active

059626674

ABSTRACT:
Estradiol facilitates non-viral gene delivery to breast tumor cells. The effect is dose dependent, and is independent of the gene construct, temperature, and tumor cell line. Thus, compositions and treatment regimens that use estradiol, or other estrogen pharmacologic agents, in combination with genes of interest can be used to provide targeted delivery and expression of genetic products in target cells and tissues of estrogen, such as breast cells. The compositions and treatment regimens have particular application to the enhanced delivery of genetic constructs useful in killing breast tumor cells and preventing tumor recurrence.

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Verma et al. (1997) Gene therapy-promises, problems and prospects. Nature 389:239-242, Sep. 1997.

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