Pharmaceuticals microencapsulated by vapor deposited polymers an

Details Pharmaceuticals microencapsulated by vapor deposited polymers an Pharmaceuticals microencapsulated by vapor deposited polymers an

1991-08-23

1994-02-22

Phelan, Gabrielle

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424400, 424443, 424458, 424469, A61K 916

Patent

active

052885046

ABSTRACT:
A microencapsulated pharmaceutical is formed by vapor depositing a polymeric film about an active pharmaceutical agent. The film thickness of the vapor deposited film is controlled to provide effective controlled release of said pharmaceutical agent subsequent to application. In a preferred embodiment the pharmaceutical is an orally ingestible pharmaceutical formed by vapor deposition of a poly-p-xylylene polymer about a core comprising an active pharmaceutical agent. The pharmaceutical agent exhibits surprising controlled release activity inspite of the extreme inertness of vapor deposited films such as Parylene films.

REFERENCES:
patent: 3117168 (1964-01-01), Gorham
patent: 3149175 (1964-09-01), Pollart
patent: 3153103 (1964-10-01), Yeh
patent: 3155712 (1964-11-01), Yeh
patent: 3164625 (1965-01-01), Pollart
patent: 3221068 (1965-11-01), Gorham
patent: 3235516 (1966-02-01), Leonard, Jr.
patent: 3240722 (1966-03-01), Orttung, Jr. et al.
patent: 3246627 (1966-04-01), Loeb et al.
patent: 3247274 (1966-04-01), Pollart
patent: 3258504 (1966-06-01), Lenaers et al.
patent: 3268599 (1966-08-01), Chow
patent: 3271470 (1966-09-01), Spence et al.
patent: 3271471 (1966-09-01), Baker et al.
patent: 3274267 (1966-09-01), Chow
patent: 3280202 (1966-10-01), Gilch
patent: 3288728 (1966-11-01), Gorham
patent: 3297591 (1967-01-01), Chow
patent: 3300332 (1967-01-01), Gorham et al.
patent: 3301707 (1967-01-01), Loeb et al.
patent: 3311668 (1967-03-01), Spence et al.
patent: 3319141 (1967-05-01), Cariou et al.
patent: 3332891 (1967-07-01), Chow et al.
patent: 3342754 (1967-09-01), Gorham
patent: 3349045 (1967-10-01), Gilch
patent: 3349147 (1967-10-01), Clay et al.
patent: 3375110 (1968-03-01), Loeb
patent: 3379803 (1968-04-01), Tittmann et al.
patent: 3395016 (1968-07-01), Loeb
patent: 3397085 (1968-08-01), Cariou et al.
patent: 3399124 (1968-08-01), Gilch
patent: 3405117 (1968-10-01), Yeh
patent: 3409410 (1968-11-01), Spence et al.
patent: 3412167 (1968-11-01), Lewis
patent: 3429739 (1969-02-01), Tittmann et al.
patent: 3440295 (1969-04-01), Capitano et al.
patent: 3472795 (1969-10-01), Tittmann et al.
patent: 3491142 (1970-01-01), Yeh et al.
patent: 3503903 (1970-01-01), Shaw et al.
patent: 3509075 (1970-04-01), Niegisch et al.
patent: 3523839 (1970-08-01), Shechter et al.
patent: 3556881 (1971-01-01), Gorham et al.
patent: 3573968 (1971-04-01), Loeb et al.
patent: 3600216 (1971-08-01), Stewart
patent: 3754015 (1973-08-01), Hedaya
patent: 3764018 (1973-10-01), Shaw et al.
patent: 3830733 (1974-08-01), Spivack et al.
patent: 3840387 (1974-10-01), Hofer
patent: 3864202 (1975-02-01), Loeb et al.
patent: 3892892 (1975-07-01), Hofer
patent: 3895135 (1975-07-01), Hofer
patent: 3936531 (1976-02-01), Hofer
patent: 4147562 (1979-04-01), Chiang et al.
patent: 4500562 (1985-02-01), Jahn et al.
patent: 4508760 (1985-04-01), Olson et al.
patent: 4758288 (1988-07-01), Versic
Kunz et al., Journal Chem. Soc. Faraday Trans., 68(1): pp. 140-149 (1972).
Schmidt, E. M.: J. Electrophysiol. Tech., 10:19-29 (1983)-"Parylene as an Electrode Insulator: A Review".
Loeb, G. E. et al.: IEEE Trans. on Biomedical Eng., BME-24(2):121-128 (Mar., 1977)-"Parylene as a Cronically Stable, Reproducible Microelectrode Insulator".
Gorham, W. F. et al.: Encyl. Polymer Science, 15:98-124 (1971).
149th ACS National Meeting, Polymer Chemistry: C & EN, 51-52 (Apr. 12, 1965).
Electronics Letters, 17(16):81080558 (Jun. 2, 1981).
Kaizer Chemicals, Brochure IC-122.
Spivack: M. A.: Corrosion-NACE, 26(9):371-375 (Sep. 1970)-"Reaction of Parylene C Coated Lithium with Water Vapor".
Hahn, A. W. et al.: J. Applied Polymer Science, Applied Polymer Symposium, 38:55-64 (1984)-"Biocompatibility of Glow-Discharge-Polymerized Films and Vacuum Deposited Parylene".
Union Carbide Brochure (c) 1971, 1974, 1976, 1979, 1985.
Tittmann, F. R. et al.: Synthetic Biomedical Polymers: Concepts and Applications, Technomic Publishing Co., 117-131 (1980)-"Parylene Coated Polypropylene Microfibers as Cell Seeding . . .".
Jayne, W. M., Jr.: Microencapsulation, Processes and Applications, 103-113 (1973-74)-"Micro-Encapsulation by Vapor Deposition".
NOVA TRAN Abstract, pp. 107 (Jan. 23, 198).

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