Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving hydrolase
Reexamination Certificate
2005-02-15
2005-02-15
Leary, Louise N. (Department: 1654)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving hydrolase
C435S018000, C435S004000, C424S009100, C424S009200, C530S300000
Reexamination Certificate
active
06855510
ABSTRACT:
Light-generating fusion proteins having a ligand binding site and a light-generating polypeptide moiety and their use as diagnostics, in drug screening and discovery, and as therapeutics, are disclosed. The light-generating fusion protein has a feature where the bioluminescence of the polypeptide moiety changes upon binding of a ligand at the ligand binding site. Tie ligand may be, for example, an enzyme present in an environment only under certain conditions, e.g., ubiquitin ligase in a hypoxic state, such that the light-generating fusion protein is “turned on” only under such conditions.
REFERENCES:
patent: 6566088 (2003-05-01), McKnight et al.
Epstein et al, “Cell”, V.107(1),pp43-54,( )ct.2001).*
Mole et al, “IUBMB life”, V.52(1-2),pp43-47,(Jul. 2001).
Ivan Mircea
Kaelin, Jr. William G.
Dana Farber Cancer Institute, Inc.
Elrifi Ivor R.
Kozakiewicz Cynthia A.
Leary Louise N.
Mintz Levin Cohn Ferris Glovsky and Popeo P.C.
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