Pharmaceuticals and assays using enzyme subunits

Details Pharmaceuticals and assays using enzyme subunits Pharmaceuticals and assays using enzyme subunits

2005-12-13

2005-12-13

Chen, Shin-Lin (Department: 1632)

Chemistry: molecular biology and microbiology

Packaged device or kit

C424S130100, C424S152100, C424S155100, C424S450000, C530S300000, C530S350000

Reexamination Certificate

active

06974699

ABSTRACT:
A method of releasing an agent for example, a chemotherapeutic, under predetermined conditions by protecting the agent within a lipid structure such as a liposome, causing lipase activity to be constituted by combining two or more components, e.g., recombinant N- or C-terminalClostridium perfringensalpha-toxin fragments, one of these components being conjugated to a targeting molecule e.g., an antibody which binds to a target such as a tumor antigen. The lipid structure is then exposed to the constituted lipase activity such as to release the agent. Also disclosed are materials and kits for use in the method.

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