Pharmaceutically useful polymorphic modification of buspirone

Details Pharmaceutically useful polymorphic modification of buspirone Pharmaceutically useful polymorphic modification of buspirone

1987-08-28

1991-05-14

Ford, John M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544230, 544295, C07D40114, A61K 31505

Patent

active

050156462

ABSTRACT:
"Buspirone hydrochloride can exist in two polymorphic forms and the newly discoverd lower melting form, which is thermodynamically favored at pharmaceutically relevant temperatures, offers advantage in manufacture of buspirone pharmaceutical compositions".

REFERENCES:
patent: 3717634 (1973-02-01), Wu et al.
patent: 3976776 (1976-08-01), Wu et al.
patent: 4351939 (1982-09-01), Simms
patent: 4476248 (1984-10-01), Gordon
Wu, et al., J. Med. Chem., 15, 477-479 (1972), (3/13).
Allen, et al., Arzneim. Forsch., 24 No. 6, 917-922 (1972), (3/16).
Sathananthan, et al., Current Therapeutic Research, 18/5, 701-705 (1975), (3/18).

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